
audiobook
by Jacques Loeb
The Organism as a Whole
PREFACE
The Organism as a Whole
CHAPTER I - INTRODUCTORY REMARKS
CHAPTER II - THE SPECIFIC DIFFERENCE BETWEEN LIVING AND DEAD MATTER AND THE QUESTION OF THE ORIGIN OF LIFE
CHAPTER III - THE CHEMICAL BASIS OF GENUS AND SPECIES
I. The Incompatibility of Species not closely Related
II. The Chemical Basis of Genus and Species and of Species Specificity
CHAPTER IV - SPECIFICITY IN FERTILIZATION
CHAPTER V - ARTIFICIAL PARTHENOGENESIS
The book tackles the age‑old puzzle of how the many parts of a living being work together as a seamless whole. It begins by acknowledging that individual physiological processes—digestion, metabolism, heat production—are clearly physico‑chemical, yet the overall harmony of organs and instincts resists a purely chemical explanation. The author also confronts the complications introduced by Mendelian genetics, which seem to fragment the organism into independent traits, and asks what binds these fragments into a coherent entity.
To answer that, the work proposes that the egg’s cytoplasm already contains the nascent embryo, providing a unifying scaffold on which genetic factors imprint specific characteristics. By examining experiments that can coax an egg to develop without sperm, the author argues that hormones, enzymes, and cytoplasmic proteins are the key mediators of species‑level unity, while Mendelian factors fine‑tune individual traits. This perspective reshapes discussions of evolution and immunity, suggesting that the broader biological design may arise from the egg’s chemistry rather than from genes alone.
Language
en
Duration
~8 hours (512K characters)
Publisher of text edition
Project Gutenberg
Release date
2014-06-14
Rights
Public domain in the USA.

1859–1924
A pioneering experimental biologist, he became famous for showing that life processes could be studied and manipulated in the laboratory. His work on animal behavior, regeneration, and artificial parthenogenesis helped shape modern physiology and embryology.
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