Synthesis of 2-methyl-4-selenoquinazolone, 2-phenylbenzoselenazole, and its derivatives Dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Faculty of Pure Science of Columbia University

Delving into the early twentieth‑century quest to unlock selenium’s chemical potential, this dissertation chronicles a systematic exploration of heterocyclic selenium compounds. The author begins by reviewing the scant literature on organic selenium, then moves to the laboratory, where a series of novel molecules—including 2‑methyl‑4‑selen­oquinazolone and various phenylbenzoselenazoles—are painstakingly synthesized and characterized.

Beyond the laboratory work, the study highlights how these new compounds exhibit striking coloration properties, often surpassing their sulfur analogues, and hints at possible pharmaceutical relevance. By comparing tinctorial behavior and handling ease, the research offers a clear window into why selenium’s unique selenocarbonyl group can act as a powerful chromophore. Listeners will gain insight into the experimental spirit of the era and the foundational chemistry that continues to inspire modern dye and drug development.